Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease
J Sjaarda, H Gerstein, M Chong et al.
KEYWORDS
biomarker; coronary artery disease; CSF1; CXCL12; genetics; Mendelian randomization;
BACKGROUND - Identification of biomarkers that cause coronary artery disease (CAD) has led to important advances in prevention and treatment. Epidemiological analyses have identified many biomarker-CAD relationships; however, these associations may arise from reverse causation and/or confounding and therefore may not represent true causal associations. Mendelian randomization (MR) analyses overcome these limitations.
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