Review Article
1999 Jan 14;340(2):115-26.
JOURNAL：N Engl J Med.
Article Link
Atherosclerosis — An Inflammatory Disease
Ross R
KEYWORDS
atherosclerosis; inflammatory disease
Atherosclerosis is an inflammatory disease. Because high plasma
concentrations of cholesterol, in particular those of low-density
lipoprotein (LDL) cholesterol, are one of the principal risk factors for
atherosclerosis,1 the process of atherogenesis has been
considered by many to consist largely of the accumulation of lipids
within the artery wall; however, it is much more than that. Despite
changes in lifestyle and the use of new pharmacologic approaches to
lower plasma cholesterol concentrations,2,3 cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.4,5 In fact, the lesions of atherosclerosis represent . . .
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