CBS 2019
CBSMD教育中心
中 文

光学相关断层扫描

Abstract

Recommended Article

Histopathological validation of optical coherence tomography findings of the coronary arteries Volumetric characterization of human coronary calcification by frequency-domain optical coherence tomography The Relation Between Optical Coherence Tomography-Detected Layered Pattern and Acute Side Branch Occlusion After Provisional Stenting of Coronary Bifurcation Lesions Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study Optical coherence tomography versus intravascular ultrasound to evaluate coronary artery disease and percutaneous coronary intervention Lipid-rich plaque and myocardial perfusion after successful stenting in patients with non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study Coronary Atherosclerosis T1-Weighed Characterization With Integrated Anatomical Reference: Comparison With High-Risk Plaque Features Detected by Invasive Coronary Imaging Optical Coherence Tomography-Guided Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction: A Prospective Propensity-Matched Cohort of the Thrombectomy Versus Percutaneous Coronary Intervention Alone Trial

Original Research

JOURNAL:CBSMD Article Link

药物涂层球囊在小血管介入中的应用

CBSMD

Pre-reading

DCB经现阶段临床试验证实在冠脉小血管狭窄干预方向与DES可一决高下,其优势在于:

1) 不改变血管解剖结构

2) 药物涂层球囊具抗血管壁增生药物,可起到预防支架内再狭窄之目的;

3) 有证据提示DCB术后DAPT服药周期可短于DES术后;

4) DCB可为后续CABG或支架置入赢取更多可能。



DCB应用在小血管介入领域时应持有的谨慎态度:

1)尽管现有指南尚未对DCB应用前腔内影像学IVUS,OCT的仔细评估做明确规定,但已有证据显示腔内影像学的先进性在指导DES置入或DCB时可转换为更好的预后;

2)应进一步明确DCB适应证及人群。



围绕DCB术后预后非劣效于DES预后的RCT研究包括:


2018年8月“Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial

样本欧洲14个介入中758例,随机比DES (paclitaxel-eluting stent) vs. DCB 1:1

病变:<3 mm直径的冠脉病变

随访:1年

DAPT:DCB组4周,DES组non-ACS患者 6周,ACS患者1年

结论: 在一年内,所有小血管疾病(< 3mm)患者随机分配到DES组和DCB组,组间MACE一年发生率无差异,符合非劣效性标准。



2018年12月“Drug-Coated Balloon Versus Drug-Eluting Stent for Small-Vessel Disease: The RESTORE SVD China Randomized Trial

样本:多中心230例

病变:2.25 ≤冠脉小血管直径 ≤2.75 mm

随访:9个月和1年

结论:9个月造影随访DCB组节段狭窄直径百分比较DES组下降了10.9%,满足非劣效标准;而一年组间靶病变失败率无统计学差异。




2019年5月“Paclitaxel-Coated Balloon Angioplasty Versus Drug-Eluting Stent in Acute Myocardial Infarction: The REVELATION Randomized Trial

样本:单中心120例

病变:STEMI, 罪犯病变非严重钙化,预扩后残余冠脉狭窄 <50%

随访:9个月FFR随访

结论:STEMI经PPCI-DCB策略干预后,其FFR评估结果非劣效于DES策略。


更多内容详细参阅Drug-Coated Balloon-Only Percutaneous Coronary Intervention for the Treatment of De Novo Coronary Artery Disease: A Systematic Review”和《紫杉醇涂层球囊的最新研究进展》。