CBS - The 17th Left Main & Coronary Bifurcation Summit, CBS2025

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Left Main & Coronary Bifurcation Summit (CBS) was founded in 2006 as a think tank dedicated to the treatment of left main and coronary bifurcation lesions. CBS aims to improve cardiological care by refreshing fundamental researches, clinical trials, yearly published guidelines, emerged ideas and case-based discussion.

Association and Affiliations
- Organized by
  
  Nanjing Heart Center
  
  Asian Bifurcation Club (ABC)
  
  Nanjing First Hospital, Nanjing Medical University
- Co-organized by
  
  Chinese Society of Cardiology (CSC)
  
  Capacity Building and Continuing Education Center,National Health and Family Planning Commission (CBCEC)
  
  American Society for Cardiovascular Angiography and Interventions (SCAI)
  
  Asian Heart Society (AHS)
Contact Us
- Registration Administration of Domestic Representatives
  
  Hongjuan Peng : +86-13913895477
  
  Haimei Xu +86-13914736846
  
  cbsnj@cbsmd.cn
- Registration Administration of Overseas Representatives
  
  Ling Lin : +86 (25) 52271398
  
  +86-13951884596
  
  cbs@cbsmd.cn
- Management of Challenging Cases
  
  Yingying Zhao :+86-13815408517
  
  sub@cbsmd.cn
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CBS2019 Congress Secretariat, Nanjing First Hospital, Building No.9 68# Changle Road, Nanjing, China

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Research Paper

> Acute Coronary Syndrom

> ASCVD Prevention

> Bifurcation Stenting

> Cardio-Oncology

> Congestive Heart Failure

> DAPT Duration

> Drug Coated Balloon

> Fractional Flow Reserve

> IVUS Guidance

> Optical Coherence Tomography

> Pulmonary Hypertension

> Rotational Atherectomy

> Shear Stress

> Stenting Left Main

> Transcatheter Aortic Valve Replacement

> Percutaneous LAA Occlusion

> Mitral/Tricuspid Valvular Disease

> Other Relevant Articles

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HOME | SCIENTIFIC LIBRARY | 血流动力学与动脉粥样硬化

血流动力学与动脉粥样硬化

Role of local coronary blood flow patterns and shear stress on the development of microvascular and epicardial endothelial dysfunction and coronary plaque Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium Low‑Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway Disturbed shear stress promotes atherosclerosis through TRIM21-regulated MAPK6 degradation and consequent endothelial inflammation

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Original Research

JOURNAL：CBSMD Article Link

第四版心肌梗死定义更新的主要内容

Salim Hayek撰, CBSMD译

Pre-reading

FACC成员Salim Haye归纳总结了第四版心肌梗死定义更新的主要内容：
1. 第四版定义明确区别心肌梗死与心肌损伤，明确指出使用心血管磁共振和CT冠脉造影用于评估急性冠脉综合征。
2. 肌钙蛋白水平应在心肌梗死发作后的最初诊疗及3-6小时后测定，高敏肌钙蛋白测试可加急(1-3小时内)测出。考虑到常规和高敏肌钙蛋白测定结果受症状发展过程中肌钙蛋白水平升高和降低的左右对制定合理的测试间隔造成的挑战，建议根据全面的临床评估结果指导取样频率和结果解读。
3. 心肌损伤的定义只有一个标准: 心肌肌钙蛋白升高，至少有一个值高于参考值上限99百分位值，因此，心肌肌钙蛋白升高是缺血和非缺血病因学中通用的术语。
4. 心肌梗死是一种由缺血导致的心肌损伤，临床证据可查为肌钙蛋白升高或至少满足以下其中一种可能：缺血性症状或心电图改变, 发展为病理性Q波，影像证据显示与缺血表现一致的新发心肌丧失或区域性室壁运动异常，血管造影或尸检可见冠状动脉血栓。
5. 1型急性心肌梗死继发于急性动脉粥样硬化血栓。2型由供氧和需求不匹配继发的缺血诱发，与急性血栓无关。3型是指在曾有心肌梗死表现，但未曾测得生物标志物，后经尸检明确的心肌缺血。
6. 4a型和5型事件分别发生在经皮冠状动脉介入治疗后(PCI)和冠状动脉旁路移植术(CABG)后48小时内，定义为肌钙蛋白升高超过先前稳定的基线值，并伴有心电图、血管造影或缺血的影像学证据。4b型定义为支架内血栓(急性<24小时，亚急性1-30天，晚期30天-1年，极晚期> PCI术后1年)，而4c型则表明PCI术后梗死区域再狭窄。
7. 心肌损伤可发生在非血运重建的心脏手术过程中，如因直接外伤或冠状动脉阻塞/栓塞后的经导管主动脉瓣置换术，除非符合5型心肌梗死的生物标志物和缺血标准，否则不归为心肌梗死。
8. 肌钙蛋白水平在急性心力衰竭、肾脏疾病、危重疾病或非心脏手术的情况下升高无专有参考值范围。以上疾病进程中合并心肌梗死的诊断应基于是否存在缺血和急性血栓的证据，已知I型和II型心肌梗死，或与缺血无关的急性心肌损伤。
9. 除非有明显的缺血表现，房颤伴快速心室率、ST段压低时的肌钙蛋白水平升高不应归入2型心肌梗死。除此之外，肌钙蛋白升高应归因于心肌损伤。
10. 非阻塞性冠状动脉疾病(MINOCA)中的心肌梗死应根据临床表现和血管造影结果分为1型(血栓再通)或2型(冠状动脉痉挛、冠状动脉夹层)。

Abstract

Recommended Article

第四版心肌梗死定义更新的主要内容

Pre-reading