Review Article
2021 Jun, 77 (24) 3058–3078
JOURNAL：J Am Coll Cardiol.
Article Link
Current Status and Future Prospects of Transcatheter Mitral Valve Replacement: JACC State-of-the-Art Review
A Alperi , JF Granada , M Bernier et al.
KEYWORDS
mitral regurgitation; TMVR; limitations
Mitral regurgitation (MR) is the most prevalent valvular heart disease
and, when left untreated, it confers a poorer prognosis. Catheter-based
repair therapies face some limitations like their applicability on
challenging anatomies and the potential recurrence of significant MR
over time. Transcatheter mitral valve replacement (TMVR) has emerged as a
less invasive approach potentially overcoming some of the current
limitations associated with transcatheter mitral valve repair. Several
devices are under clinical investigation, and a growing number of
systems allow for a fully percutaneous transfemoral approach. In this
review, the authors aimed to delineate the main challenges faced by the
TMVR field, to highlight the key aspects for procedural planning, and to
describe the clinical results of the TMVR systems under clinical
investigation. Finally, they also discuss what the future perspectives
are for this emerging field.
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