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血流储备分数

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Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty Utilization and Outcomes of Measuring Fractional Flow Reserve in Patients With Stable Ischemic Heart Disease Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction Coronary Microcirculation Downstream Non-Infarct-Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology-Guided Revascularization Coronary Flow Reserve in the Instantaneous Wave-Free Ratio/Fractional Flow Reserve Era: Too Valuable to Be Neglected Prognostic Implications of Plaque Characteristics and Stenosis Severity in Patients With Coronary Artery Disease Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity The impact of downstream coronary stenoses on fractional flow reserve assessment of intermediate left main disease Comparison of Coronary Computed Tomography Angiography, Fractional Flow Reserve, and Perfusion Imaging for Ischemia Diagnosis
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Original Research30 December 2019

JOURNAL：European Heart Journal Article Link

Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation

SX Tu, J Westra, J Adjedj et al. Keywords: coronary angiography; fractional coronary flow reserve; intravascular ultrasonography; bone wires; catheterization; constriction; pathologic diagnosis; diagnostic imaging; physiology; revascularization

ABSTRACT

Fractional flow reserve (FFR) and instantaneous wave-free ratio are the present standard diagnostic methods for invasive assessment of the functional significance of epicardial coronary stenosis. Despite the overall trend towards more physiology-guided revascularization, there remains a gap between guideline recommendations and the clinical adoption of functional evaluation of stenosis severity. A number of image-based approaches have been proposed to compute FFR without the use of pressure wire and induced hyperaemia. In order to better understand these emerging technologies, we sought to highlight the principles, diagnostic performance, clinical applications, practical aspects, and current challenges of computational physiology in the catheterization laboratory. Computational FFR has the potential to expand and facilitate the use of physiology for diagnosis, procedural guidance, and evaluation of therapies, with anticipated impact on resource utilization and patient outcomes.

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