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肺动脉高压

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Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) Immunotherapy of Endothelin-1 Receptor Type A for Pulmonary Arterial Hypertension Pulmonary Hypertension Caused by a Coconut Left Atrium Left main coronary artery compression in pulmonary hypertension Updated clinical classification of pulmonary hypertension Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study Pulmonary Artery Denervation: An Alternative Therapy for Pulmonary Hypertension Update on chronic thromboembolic pulmonary hypertension Risk Stratification in PAH Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease

Original Research1993 Mar;103(3):685-92.

JOURNAL:Chest. Article Link

Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension

Moser KM, Bloor CM. Keywords: CTEPH;

ABSTRACT


The status of small pulmonary arteries may influence diagnosis, surgical selection and postoperative outcome of patients with chronic major vessel thromboembolic pulmonary hypertension (CTEPH). Therefore, in patients with the established diagnosis of CTEPH, lung tissue was obtained by biopsy (15 patients) or at autopsy (16 patients) to assess the histopathologic composition of small pulmonary arteries. Pathologic examination disclosed the full range of pulmonary hypertensive lesions in the small arteries, including plexogenic lesions. The type and extent of hypertensive lesions did not relate to preoperative hemodynamic values, to patient age, or to symptom duration. The findings indicate that primary pulmonary hypertension cannot be differentiated from potentially correctable CTEPH on the basis of histopathologic findings in small pulmonary arteries. Furthermore, none of the histologic findings preclude a positive hemodynamic and clinical result from pulmonary thromboendarterectomy. However, development of these hypertensive changes may explain the deterioration which these patients experience preoperatively over time.