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ACS Management in a Patient in Need of Noncardiac Surgery Cardiovascular effects of radiation therapy Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs Longitudinal Assessment of Vascular Function With Sunitinib in Patients With Metastatic Renal Cell Carcinoma Abnormalities in 3-Dimensional Left Ventricular Mechanics With Anthracycline Chemotherapy Are Associated With Systolic and Diastolic Dysfunction Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease: JACC State-of-the-Art Review Apixaban to Prevent Venous Thromboembolism in Patients with Cancer Cardiotoxicity and Cardiac Monitoring Among Chemotherapy-Treated Breast Cancer Patients Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement Drug-Drug Interactions of Common Cardiac Medications and Chemotherapeutic Agents
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Review Article2018 Mar 13;137(11):1176-1191.

JOURNAL：Circulation Article Link

Exercise Therapy and Cardiovascular Toxicity in Cancer

Scott JM, Nilsen TS, Gupta D et al. Keywords: cardiorespiratory fitness; cardiotoxicity; exercise; heart failure; survivorship

ABSTRACT

Cardio-oncology is an emerging discipline focused predominantly on the detection and management of cancer treatment-induced cardiac dysfunction (cardiotoxicity), which predisposes to development of overt heart failure or coronary artery disease. The direct adverse consequences, as well as those secondary to anticancer therapeutics, extend beyond the heart, however, to affect the entire cardiovascular-skeletal muscle axis (ie, whole-organism cardiovascular toxicity). The global nature of impairment creates a strong rationale for treatment strategies that augment or preserve global cardiovascular reserve capacity. In noncancer clinical populations, exercise training is an established therapy to improve cardiovascular reserve capacity, leading to concomitant reductions in cardiovascular morbidity and its attendant symptoms. Here, we overview the tolerability and efficacy of exercise on cardiovascular toxicity in adult patients with cancer. We also propose a conceptual research framework to facilitate personalized risk assessment and the development of targeted exercise prescriptions to optimally prevent or manage cardiovascular toxicity after a cancer diagnosis.

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