CBS 2019
CBSMD教育中心
中 文

推荐文献

Abstract

Recommended Article

A Combination of Allogeneic Stem Cells Promotes Cardiac Regeneration Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Association Between Living in Food Deserts and Cardiovascular Risk Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity Burden of 30-Day Readmissions After Percutaneous Coronary Intervention in 833,344 Patients in the United States: Predictors, Causes, and Cost Mode of Death in Heart Failure With Preserved Ejection Fraction
|<<... 6 7 8 9 10 11 12 ...>>|

Original ResearchVolume 75, Issue 14, April 2020

JOURNAL：JACC Article Link

Long-Term Outcomes in Women and Men Following Percutaneous Coronary Intervention

I Kosmidou, R Mehran, GW Stone et al. Keywords: mortality; outcomes; PCI; sex

ABSTRACT

BACKGROUND - Studies examining sex-related outcomes following percutaneous coronary intervention (PCI) have reported conflicting results.

 

OBJECTIVES - The purpose of this study was to examine the sex-related risk of 5-year cardiovascular outcomes after PCI.

 

METHODS - The authors pooled patient-level data from 21 randomized PCI trials and assessed the association between sex and major adverse cardiac events (MACE) (cardiac death, myocardial infarction [MI], or ischemia-driven target lesion revascularization [ID-TLR]) as well as its individual components at 5 years.

 

RESULTS - Among 32,877 patients, 9,141 (27.8%) were women. Women were older and had higher body mass index, more frequent hypertension and diabetes, and less frequent history of surgical or percutaneous revascularization compared with men. By angiographic core laboratory analysis, lesions in women had smaller reference vessel diameter and shorter lesion length. At 5 years, women had a higher unadjusted rate of MACE (18.9% vs. 17.7%; p = 0.003), all-cause death (10.4% vs. 8.7%; p = 0.0008), cardiac death (4.9% vs. 4.0%; p = 0.003) and ID-TLR (10.9% vs. 10.2%; p = 0.02) compared with men. By multivariable analysis, female sex was an independent predictor of MACE (hazard ratio [HR:]: 1.14; 95% confidence interval [CI:]: 1.01 to 1.30; p = 0.04) and ID-TLR (HR: 1.23; 95% CI: 1.05 to 1.44; p = 0.009) but not all-cause death (HR: 0.91; 95% CI: 0.75 to 1.09; p = 0.30) or cardiac death (HR: 0.97; 95% CI: 0.73 to 1.29; p = 0.85).

 

CONCLUSIONS - In the present large-scale, individual patient data pooled analysis of contemporary PCI trials, women had a higher risk of MACE and ID-TLR compared with men at 5 years following PCI.

>CBS CBS 2019

> CBS 2019 REGISTRATION

> CBS 2019 PROGRAM

> CBS 2019 CALL FOR SCIENCE

> CBS 2019 SPOTLIGHTS

 CBSMD

> CBSMD WEBSITE REGISTRATION

> EDUCATION CENTER

> RECOMMANDED PAPER

> TOP 10 RESEARCH PAPER

> PRE-READING

CBS 2019 CBS 2019 FACULTY Education Resource CBSMD Scientific Library
Copyright ⓒ CBS MD Nanjing China. All rights reserved. 京ICP备16025898号-11
联系我们| Top