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Fractional Flow Reserve

Abstract

Recommended Article

Clinical Relevance of Functionally Insignificant Moderate Coronary Artery Stenosis Assessed by 3-Vessel Fractional Flow Reserve Measurement Coronary Computed Tomography–Based Fractional Flow Reserve A Rapidly Developing Field Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease High-Resolution Cardiac Magnetic Resonance Imaging Techniques for the Identification of Coronary Microvascular Dysfunction Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis Impact of myocardial supply area on the transstenotic hemodynamics as determined by fractional flow reserve Diagnostic Performance of the Instantaneous Wave-Free Ratio: Comparison With Fractional Flow Reserve Influence of Heart Rate on FFR Measurements: An Experimental and Clinical Validation Study
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Original Research30 December 2019

JOURNAL：European Heart Journal Article Link

Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation

SX Tu, J Westra, J Adjedj et al. Keywords: coronary angiography; fractional coronary flow reserve; intravascular ultrasonography; bone wires; catheterization; constriction; pathologic diagnosis; diagnostic imaging; physiology; revascularization

ABSTRACT

Fractional flow reserve (FFR) and instantaneous wave-free ratio are the present standard diagnostic methods for invasive assessment of the functional significance of epicardial coronary stenosis. Despite the overall trend towards more physiology-guided revascularization, there remains a gap between guideline recommendations and the clinical adoption of functional evaluation of stenosis severity. A number of image-based approaches have been proposed to compute FFR without the use of pressure wire and induced hyperaemia. In order to better understand these emerging technologies, we sought to highlight the principles, diagnostic performance, clinical applications, practical aspects, and current challenges of computational physiology in the catheterization laboratory. Computational FFR has the potential to expand and facilitate the use of physiology for diagnosis, procedural guidance, and evaluation of therapies, with anticipated impact on resource utilization and patient outcomes.

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