CBS 2019
CBSMD教育中心
中 文

充血性心力衰竭

Abstract

Recommended Article

Nuclear Imaging of the Cardiac Sympathetic Nervous System: A Disease-Specific Interpretation in Heart Failure The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure Natriuretic Peptide-Guided Heart Failure Therapy After the GUIDE-IT Study A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF) Primary Prevention of Heart Failure in Women Permanent pacemaker use among patients with heart failure and preserved ejection fraction: Findings from the Acute Decompensated Heart Failure National Registry (ADHERE) National Registry Modifiable lifestyle factors and heart failure: A Mendelian randomization study Impact of Myocardial Scar on Prognostic Implication of Secondary Mitral Regurgitation in Heart Failure

Review ArticleVolume 73, Issue 17, May 2019

JOURNAL:J Am Coll Cardiol. Article Link

Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review

M.G.D Buono, R Arena, BA Borlaug et al. Keywords: cardiorespiratory fitness; HFrEF; HFpEF; exercise capacity; comorbidities

ABSTRACT


Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance, because it is associated with a poor quality of life and increased mortality. While impaired cardiac reserve is considered to be central in HF, reduced exercise and functional capacity are the result of key patient characteristics and multisystem dysfunction, including aging, impaired pulmonary reserve, as well as peripheral and respiratory skeletal muscle dysfunction. We herein review the different modalities to quantify exercise intolerance, the pathophysiology of HF, and comorbid conditions as they lead to reductions in exercise and functional capacity, highlighting the fact that distinct causes may coexist and variably contribute to exercise intolerance in patients with HF.