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ASCVD Prevention

Abstract

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Treatment and prevention of lipoprotein(a)-mediated cardiovascular disease: the emerging potential of RNA interference therapeutics Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular DiseaseA Prespecified Analysis From the FOURIER Trial Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography Identifying coronary artery disease patients at risk for sudden and/or arrhythmic death: remaining limitations of the electrocardiogram The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults

Review Article1999 Jan 14;340(2):115-26.

JOURNAL:N Engl J Med. Article Link

Atherosclerosis — An Inflammatory Disease

Ross R Keywords: atherosclerosis; inflammatory disease

First 100 Words

Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis,1 the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations,2,3 cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.4,5 In fact, the lesions of atherosclerosis represent . . .