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ASCVD Prevention

Abstract

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How Far We Have Come, How Far We Have Yet to Go in Atherosclerosis Research In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events Initial Invasive or Conservative Strategy for Stable Coronary Disease Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies Targeting the Immune System in Atherosclerosis: JACC State-of-the-Art Review Plaque Rupture, compared to Plaque Erosion, is associated with Higher Level of Pan-coronary Inflammation Association of White Matter Hyperintensities and Cardiovascular Disease: The Importance of Microcirculatory Disease Association Between Depressive Symptoms and Incident Cardiovascular Diseases
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Review Article2021 Feb 10;heartjnl-2020-318269.

JOURNAL：Heart. Article Link

MINOCA: a heterogenous group of conditions associated with myocardial damage

T Singh, AR Chapman, NL Mills et al. Keywords: myocardial damage; MINOCA

ABSTRACT

Myocardial infarction with non-obstructive coronary arteries (MINOCA) was first described over 80 years ago. The term has been widely and inconsistently used in clinical practice, influencing various aspects of disease classification, investigation and management. MINOCA encompasses a heterogenous group of conditions that include both atherosclerotic and non-atherosclerotic disease resulting in myocardial damage that is not due to obstructive coronary artery disease. In many ways, it is a term that describes a moment in the diagnostic pathway of the patient and is arguably not a diagnosis. Central to the definition is also the distinction between myocardial infarction and injury. The universal definition of myocardial infarction distinguishes acute myocardial infarction, including those with MINOCA, from other causes of myocardial injury by the presence of clinical evidence of ischaemia. However, these ischaemic features are often non-specific causing diagnostic confusion, and can create difficulties for patient management and follow-up. The purpose of this review is to summarise our current understanding of MINOCA and highlight important issues relating to the diagnosis, investigation and management of patients with MINOCA.
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