CBS 2019
CBSMD教育中心
中 文

ASCVD Prevention

Abstract

Recommended Article

Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies How Far We Have Come, How Far We Have Yet to Go in Atherosclerosis Research In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events Association of White Matter Hyperintensities and Cardiovascular Disease: The Importance of Microcirculatory Disease Association Between Depressive Symptoms and Incident Cardiovascular Diseases Initial Invasive or Conservative Strategy for Stable Coronary Disease Targeting the Immune System in Atherosclerosis: JACC State-of-the-Art Review Plaque Rupture, compared to Plaque Erosion, is associated with Higher Level of Pan-coronary Inflammation
|<<... 12 13 14 15 16 17 18 >>|

Original ResearchNov 08, 2021.

JOURNAL：J Am Coll Cardiol Img. Article Link

Plaque Rupture, compared to Plaque Erosion, is associated with Higher Level of Pan-coronary Inflammation

A Nakajima , T Sugiyama , M Araki et al. Keywords: plaque rupture; plaque erosion; inflammation; ASCVD;

ABSTRACT

BACKGROUND - Vascular inflammation plays a key role in plaque rupture, while the role of inflammation in plaque erosion remains less well defined. Peri-coronary adipose tissue (PCAT) attenuation determined by computed tomography has emerged as a marker specific for coronary artery inflammation.

 

OBJECTIVES - To compare the level of coronary inflammation between plaque rupture and plaque erosion using PCAT attenuation.

 

METHODS - Patients with non-ST-segment elevation acute coronary syndromes who underwent pre-intervention coronary computed tomography angiography and optical coherence tomography culprit lesion imaging were enrolled. PCAT attenuation was measured around the culprit lesion and in the proximal 40mm of all coronary arteries.

 

RESULTS - Out of 198 patients, plaque rupture was the underlying mechanism in 107 patients (54.0%) and plaque erosion in 91 (46.0%) patients. Plaque rupture had higher PCAT attenuation than plaque erosion both at the culprit plaque level (-65.8 ± 7.5 vs. -69.5 ± 11.4 Hounsfield unit [HU], p = 0.010) and at the culprit vessel level (-67.1 ± 7.1 vs. -69.6 ± 8.2 HU, p = 0.024). The mean PCAT attenuation of all 3 coronary arteries was also significantly higher in patients with plaque rupture than in plaque erosion indicating a higher level of inflammation (-67.9 ± 5.7 vs. -69.9 ± 6.8 HU, p = 0.030). In multivariable analysis, plaque rupture was significantly associated with high PCAT attenuation.

 

CONCLUSIONS - PCAT attenuation in culprit plaque, culprit vessel, and all 3 coronary arteries was higher in plaque rupture than in plaque erosion. The results suggest pan-coronary inflammation plays a more significant role in plaque rupture than in plaque erosion.

>CBS CBS 2019

> CBS 2019 REGISTRATION

> CBS 2019 PROGRAM

> CBS 2019 CALL FOR SCIENCE

> CBS 2019 SPOTLIGHTS

 CBSMD

> CBSMD WEBSITE REGISTRATION

> EDUCATION CENTER

> RECOMMANDED PAPER

> TOP 10 RESEARCH PAPER

> PRE-READING

CBS 2019 CBS 2019 FACULTY Education Resource CBSMD Scientific Library
Copyright ⓒ CBS MD Nanjing China. All rights reserved. 京ICP备16025898号-11
联系我们| Top