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Original Research2020 Jul 27.

JOURNAL：Neuroendocrinology. Article Link

Cardiac Metastases in Patients with Neuroendocrine Tumours: Clinical Features, Therapy Outcomes, and Prognostic Implications

M Liu, E Armeni, S Navalkissoor et al. Keywords: adenosine; arthritis; ticagrelor vs. clopidogrel; osteoarthritis

ABSTRACT

BACKGROUND - Cardiac metastases (CM) from neuroendocrine tumours (NET) are rare, however with the introduction of new molecular imaging modalities, such as 68Ga-DOTATATE PET-CT for NET diagnosis and re-staging, they are now identified more frequently. This study presents a single-institution experience on the NET CM characteristics, management and prognostic implications.


METHODS - Between January 1998 and January 2020, 25 NET patients with CM were treated in our Unit. A retrospective review of electronic records was performed. Overall survival (OS) was assessed by the Kaplan-Meier method. Cox regression models were used to evaluate the association of various clinical variables with OS.


RESULTS - The median age in the NET CM cohort was 64 years, with small intestine being the most common primary (84%). Nearly half of the patients suffered either from shortness of breath (48%) or had palpitations (12%). Peptide Receptor Radionuclide Therapy (PRRT) was applied in more than half of the patients (64%), who had an improved-trend for a longer median OS compared to those patients who did not receive PRRT (76.0 vs. 14.0 months, p = 0.196). The multivariate analysis demonstrated that concomitant skeletal or pancreatic metastases, as well as N-terminal Pro-B-type Natriuretic Peptide (NT pro-BNP) > 2 × upper limit of normal (ULN) were independent poor prognosticators.


CONCLUSIONS - Clinical features of NET CM ranged from asymptomatic patients to heart failure. Concomitant bone or pancreatic metastases and NT pro-BNP levels > 2 ULN predicted shorter survival time. PRRT serves as a feasible therapy with promising survival benefits, however more data are needed.


© 2020 S. Karger AG, Basel.

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