CBS - The 17th Left Main & Coronary Bifurcation Summit, CBS2025

科学研究

Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis Comparative efficacy of two paclitaxel-coated balloons with different excipient coatings in patients with coronary in-stent restenosis: A pooled analysis of the Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In-Stent Restenosis 3 and 4 trials Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE Registry Percutaneous coronary intervention for the left main stem and other bifurcation lesions: 12th consensus document from the European Bifurcation Club ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture Transthoracic echocardiography for the evaluation of children and adolescents with suspected or confirmed pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and D6PK Evolving understanding of the heterogeneous natural history of individual coronary artery plaques and the role of local endothelial shear stress

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Original ResearchVolume 75, Issue 7, February 2020

JOURNAL：J Am Coll Cardiol. Article Link

Long-Term Exposure to Fine Particulate Matter and Cardiovascular Disease in China

FC Liang, FC Liu, DF Gu et al. Keywords: cardiovascular diseases; cohort study; incidence and mortality; long-term exposure; satellite-based PM2.5 estimation

ABSTRACT

BACKGROUND - Evidence of the effects of long-term fine particulate matter (PM_2.5) exposure on cardiovascular diseases (CVDs) is rare for populations exposed to high levels of PM_2.5 in China and in other countries with similarly high levels.

OBJECTIVES - The aim of this study was to assess the CVD risks associated with long-term exposure to PM_2.5 in China.

METHODS - A nationwide cohort study, China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China), was used, with 116,972 adults without CVD in 2000 being included. Participants were followed until 2015. Satellite-based PM_2.5 concentrations at 1-km spatial resolution during the study period were used for exposure assessment. A Cox proportional hazards model with time-varying exposures was used to estimate the CVD risks associated with PM_2.5 exposure, adjusting for individual risk factors.

RESULTS - Annual mean concentrations of PM_2.5 at the China-PAR sites ranged from 25.5 to 114.0 μg/m³. For each 10 μg/m³ increase in PM_2.5 exposures, the multivariate-adjusted hazard ratio was 1.251 (95% confidence interval: 1.220 to 1.283) for CVD incidence and 1.164 (95% confidence interval: 1.117 to 1.213) for CVD mortality. The slopes of concentration-response functions of PM_2.5 exposure and CVD risks were steeper at high PM_2.5 levels. In addition, older residents, rural residents, and never smokers were more prone to adverse effects of PM_2.5 exposure.

CONCLUSIONS - This study provides evidence that elevated long-term PM_2.5 exposures lead to increased CVD risk in China. The effects are more pronounced at higher PM_2.5 levels. These findings expand the current knowledge on adverse health effects of severe air pollution and highlight the potential cardiovascular benefits of air quality improvement in China and other low- and middle-income countries.

Abstract

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Long-Term Exposure to Fine Particulate Matter and Cardiovascular Disease in China

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