CBS 2019
CBSMD教育中心
中 文

科学研究

Abstract

Recommended Article

Diagnostic performance of stress perfusion cardiac magnetic resonance for the detection of coronary artery disease: A systematic review and meta-analysis Impact of Optimized Procedure-Related Factors in Drug-Eluting Balloon Angioplasty for Treatment of In-Stent Restenosis Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial Acute Myocardial Injury in Patients Hospitalized With COVID-19 Infection: A Review Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States Healed Culprit Plaques in Patients With Acute Coronary Syndromes Prevalence and Prognosis of Unrecognized Myocardial Infarction Determined by Cardiac Magnetic Resonance in Older Adults The Prognostic Value of Exercise Echocardiography After Percutaneous Coronary Intervention

Review Article2017 Aug 1;70(5):590-606.

JOURNAL:J Am Coll Cardiol. Article Link

Translational Perspective on Epigenetics in Cardiovascular Disease

van der Harst P, de Windt LJ, Chambers JC Keywords: EWAS; HAT; HDAC; RNA; histones; methylation

ABSTRACT

A plethora of environmental and behavioral factors interact, resulting in changes in gene expression and providing a basis for the development and progression of cardiovascular diseases. Heterogeneity in gene expression responses among cells and individuals involves epigenetic mechanisms. Advancing technology allowing genome-scale interrogation of epigenetic marks provides a rapidly expanding view of the complexity and diversity of the epigenome. In this review, the authors discuss the expanding landscape of epigenetic modifications and highlight their importance for future understanding of disease. The epigenome provides a mechanistic link between environmental exposures and gene expression profiles ultimately leading to disease. The authors discuss the current evidence for transgenerational epigenetic inheritance and summarize the data linking epigenetics to cardiovascular disease. Furthermore, the potential targets provided by the epigenome for the development of future diagnostics, preventive strategies, and therapy for cardiovascular disease are reviewed. Finally, the authors provide some suggestions for future directions.