CBS 2019
CBSMD教育中心
中 文

经导管主动脉瓣置换

Abstract

Recommended Article

Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR: An Analysis of the PARTNER Trials and Registries Risk of Coronary Obstruction and Feasibility of Coronary Access After Repeat Transcatheter Aortic Valve Replacement With the Self-Expanding Evolut Valve: A Computed Tomography Simulation Study Comparison of newer generation self-expandable vs. balloon-expandable valves in transcatheter aortic valve implantation: the randomized SOLVE-TAVI trial Thrombotic Versus Bleeding Risk After Transcatheter Aortic Valve Replacement: JACC Review Topic of the Week Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR Valve‐in‐Valve for Degenerated Transcatheter Aortic Valve Replacement Versus Valve‐in‐Valve for Degenerated Surgical Aortic Bioprostheses: A 3‐Center Comparison of Hemodynamic and 1‐Year Outcome Comparison of 1-Year Pre- And Post-Transcatheter Aortic Valve Replacement Hospitalization Rates: A Population-Based Cohort Study Transcatheter Aortic Valve Replacement in Patients With Multivalvular Heart Disease
|<<... 8 9 10 11 12 13 14 ...>>|

Original Research2019 Jan 15. [Epub ahead of print]

JOURNAL：EuroIntervention. Article Link

The Prevalence of Myocardial Bridging Associated with Coronary Endothelial Dysfunction in Patients with Chest Pain and Non-Obstructive Coronary Artery Disease

Sara JDS, Corban MT, Prasad M et al. Keywords: myocardial bridging; prevalence; coronary endothelial dysfunction; chest pain; angina; non obstructive CAD

ABSTRACT

AIMS - Myocardial bridging (MB), characterized by the epicardial coronary vessel diving into the myocardium, is present up to 1/3rd of adults and is associated with accelerated atherosclerosis, and angina. In the current study we determine the association between MB and coronary endothelial dysfunction.


METHODS AND RESULTS - Patients with chest pain and nonobstructive CAD (stenosis < 40%) at angiography underwent invasive assessment of endothelial function. Epicardial endothelial function was assessed by measuring the percent change in coronary artery diameter in response to intracoronary infusions of acetylcholine (%ΔCADAch). Epicardial endothelial dysfunction was defined as %ΔCADAch of < -20%. Microvascular endothelial function was assessed as the percent change in coronary blood flow in response to intracoronary infusions of acetylcholine (%ΔCBFAch), and microvascular endothelial dysfunction was defined as %ΔCBFAch of < 50%. MB was diagnosed angiographically. The frequency of epicardial and microvascular endothelial dysfunction was compared between patients with and without MB. Results Between 1993 and 2012, 1,469 patients (mean age 50.4 years, 35% male) underwent coronary angiography and invasive testing of endothelial function. Two hundred eight (14.2%) patients had MB. Patients with MB had a higher frequency of epicardial endothelial dysfunction compared to patients without MB. In multivariate analyses, MB was a significant predictor of epicardial (OR, 95% CI, 1.45, 1.05 - 2.01, p=0.026) and microvascular endothelial dysfunction (OR, 95% CI, 1.36, 1.00 - 1.85, p=0.047).


CONCLUSIONS - MB is significantly associated with epicardial and microvascular endothelial dysfunction in patients with non-obstructive CAD supporting its potential role as a mechanism for angina in symptomatic patients with MB.

>CBS CBS 2019

> CBS 2019 REGISTRATION

> CBS 2019 PROGRAM

> CBS 2019 CALL FOR SCIENCE

> CBS 2019 SPOTLIGHTS

 CBSMD

> CBSMD WEBSITE REGISTRATION

> EDUCATION CENTER

> RECOMMANDED PAPER

> TOP 10 RESEARCH PAPER

> PRE-READING

CBS 2019 CBS 2019 FACULTY Education Resource CBSMD Scientific Library
Copyright ⓒ CBS MD Nanjing China. All rights reserved. 京ICP备16025898号-11
联系我们| Top