Abstract - The Left Main and Coronary Artery Bifurcation Lesion Summit (CBS)

Abstract

Analysis of reperfusion time trends in patients with ST-elevation myocardial infarction across New York State from 2004 to 2012
Society of cardiac angiography and interventions: suggested management of the no-reflow phenomenon in the cardiac catheterization laboratory
The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics
Outcomes of off- and on-hours admission in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: A retrospective observational cohort study
2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society
Reappraisal of Reported Genes for Sudden Arrhythmic Death: An Evidence-Based Evaluation of Gene Validity for Brugada Syndrome
Impact of door-to-balloon time on long-term mortality in high- and low-risk patients with ST-elevation myocardial infarction
Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial
Is Acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF
Causes of delay and associated mortality in patients transferred with ST-segment-elevation myocardial infarction

Original Research

2017 Apr 1;232:140-146.

JOURNAL：Int J Cardiol.

Analysis of reperfusion time trends in patients with ST-elevation myocardial infarction across New York State from 2004 to 2012

Al'Aref SJ, Wong SC, Minutello RM et al.

9890

Keywords: Mortality; Myocardial infarction; Reperfusion times

ABSTRACT

BACKGROUND - Registry-driven data have shown a significant decrease in door-to-balloon (DTB) times in patients with ST-elevation myocardial infarction (STEMI) receiving percutaneous coronary intervention (PCI). We sought to determine the trends in reperfusion times (symptom-onset to door (SOTD) and DTB times) in patients presenting with STEMI across New York State.

METHODS - We retrospectively examined 35,613 STEMI patients receiving PCI from 2004 to 2012 and compared median SOTD and DTB times across years. Patients with SOTD time >12h and DTB time >3h were excluded.

RESULTS - There was a statistically significant trend towards shorter DTB times (median DTB time of 83min (IQR 53, 116) in 2004 to a median DTB time of 59min (IQR 40, 78) in 2012, P<0.01 for trend) and SOTD times (median SOTD time of 127min (IQR 64, 241) in 2004 to a median SOTD time of 116min (IQR 60, 205) in 2012, P<0.01 for trend). In subgroup analysis, demographics and the presence of co-morbid conditions did not influence the trend in reperfusion times. However, women had longer reperfusion times than men in 2012. After adjusting for confounding variables, DTB was a significant predictor of in-hospital mortality (HR=1.04 (per 10minutes), P<0.01).

CONCLUSIONS - There was a significant decrease in reperfusion times from 2004 to 2012 in STEMI patients across New York State. This trend was significant regardless of the presence of co-morbid conditions, although a significant gap in reperfusion times persists between men and women.