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Left Ventricular Assist Devices for Lifelong Support Qualitative Methodology in Cardiovascular Outcomes Research: A Contemporary Look Coronary Artery Calcium Is Associated with Left Ventricular Diastolic Function Independent of Myocardial Ischemia Advances in Coronary No-Reflow Phenomenon-a Contemporary Review 2-Year Outcomes After Stenting of Lipid-Rich and Nonrich Coronary Plaques Management of two major complications in the cardiac catheterisation laboratory: the no-reflow phenomenon and coronary perforations Long-Term Outcomes of Biodegradable Versus Second-Generation Durable Polymer Drug-Eluting Stent Implantations for Myocardial Infarction Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction Effect of Aspirin on All-Cause Mortality in the Healthy Elderly Radionuclide Image-Guided Repair of the Heart
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Review Article2017 Jun 13;69(23):2845-2861. ​

JOURNAL：J Am Coll Cardiol. Article Link

Left Ventricular Assist Devices for Lifelong Support

Pinney SP, Anyanwu AC, Lala A et al. Keywords: cardiothoracic surgery; heart failure; hemocompatibility

ABSTRACT


Continuous-flow left ventricular assist devices (LVADs) have revolutionized advanced heart failure care. These compact, fully implantable heart pumps are capable of providing meaningful increases in survival, functional capacity, and quality of life. Implantation volumes continue to grow, but several challenges remain to be overcome before LVADs will be considered as the therapy of choice for all patients with advanced heart failure. They must be able to consistently extend survival for the long term (7 to 10 years), rather than the midterm (3 to 5 years) more typical of contemporary devices; they must incorporate design elements that reduce shear stress and avoid stasis to reduce the frequent adverse events of bleeding, stroke, and pump thrombosis; and they must become more cost-effective. The advancements in engineering, implantation technique, and medical management detailed in this review will highlight the progress made toward achieving lifelong LVAD support and the challenges that remain.


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