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Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial Treating Multivessel Coronary Artery Disease in ST-Segment Elevation Myocardial Infarction: Why, How, and When? Incidence and Outcomes of Acute Coronary Syndrome After Transcatheter Aortic Valve Replacement Complete Versus Culprit-Only Revascularization in STEMI: a Contemporary Review Elective Coronary Revascularization Procedures in Patients With Stable Coronary Artery Disease: Incidence, Determinants, and Outcome (From the CORONOR Study) Relations between implementation of new treatments and improved outcomes in patients with non-ST-elevation myocardial infarction during the last 20 years: experiences from SWEDEHEART registry 1995 to 2014 Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS Restenosis, Stent Thrombosis, and Bleeding Complications - Navigating Between Scylla and Charybdis Impact of Off-Hours Versus On-Hours Primary Percutaneous Coronary Intervention on Myocardial Damage and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction

Clinical Trial2010 Nov;340(5):356-9.

JOURNAL:Am J Med Sci. Article Link

Respiratory syncytial virus infection and risk of acute myocardial infarction

Guan XR, Jiang LX, Ma XH et al. Keywords: Respiratory syncytial virus, Infection, Acute myocardial infarction

ABSTRACT


INTRODUCTION - Increasing evidences have shown that pathogens may promote atherosclerosis and trigger acute myocardial infarction (AMI). There is no report on the association between respiratory syncytial virus (RSV) infection and AMI. The case-control study was used to assess the association of previous RSV infection and acute myocardial infarction.


METHODS - AMI cases and non-AMI controls were recruited from patients at a large teaching hospital in Harbin, China, during October 1, 2005, to March 31, 2006, and October 1, 2006, to March 31, 2007. Questionnaire survey was conducted to collect information on demographic characteristics and heart disease risk factors. Fasting blood sample was obtained to measure immunoglobulin G antibodies to RSV, Cytomegalovirus, herpes simplex virus type-1 and type-2, adenovirus, Rubella virus, Chlamydia pneumoniae and Helicobacter pylori and to measure the level of cholesterol, fasting serum glucose, triglycerides and high-sensitivity C-reactive protein.

RESULTS - AMI group had more smokers than controls (56.9% versus 18.0%) and were more likely to have positive immunoglobulin G antibodies to RSV (OR, 6.2; 95% CI, 3.5-10.7; P < 0.001). After adjustment for potential confounding variables, the association between RSV and AMI remained (adjusted odds ratio, 11.1; 95% confidence interval, 3.3-29.5).

CONCLUSIONS - Our study supported the hypothesis that the previous RSV infection was associated with AMI. This indicates that prevention and proper treatment of RSV infection are of great clinical importance for the reduction of AMI risk.