CBS 2019
CBSMD教育中心
中 文

Congestive Heart Failure

Abstract

Recommended Article

Proteomics to Improve Phenotyping in Obese Patients with Heart Failure with Preserved Ejection Fraction Criteria for Iron Deficiency in Patients With Heart Failure 21st Century CE: The New Iron Age? 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure AIM2-driven inflammasome activation in heart failure Seattle Heart Failure and Proportional Risk Models Predict Benefit From Implantable Cardioverter-Defibrillators Impact of Myocardial Scar on Prognostic Implication of Secondary Mitral Regurgitation in Heart Failure

Review ArticleVolume 13, Issue 4, April 2020

JOURNAL:JACC: Cardiovascular Imaging Article Link

Nuclear Imaging of the Cardiac Sympathetic Nervous System: A Disease-Specific Interpretation in Heart Failure

JGE Zelt, RA deKemp, BH Rotstein et al. Keywords: positron emissions tomography; sympathetic nervous system; sympathetic nervous system radioisotopes

ABSTRACT

Abnormalities in the cardiac sympathetic nervous system have been documented in various heart diseases and have been directly implicated in their pathogenesis and disease progression. Noninvasive techniques using single-photon-emitting radiotracers for planar scintigraphy and single-photon emission computed tomography, and positron-emitting tracers for positron emissions tomography, have been used to characterize the cardiac sympathetic nervous system with norepinephrine analogs [123I]meta-iodobenzylguanidine for planar and single-photon emission computed tomography imaging and [11C]meta-hydroxyephedrine for positron emissions tomography. Their usefulness in prognostication and risk stratification for cardiac events has been demonstrated. This review bridges basic and clinical research and focuses on applying an understanding of tracer kinetics and neuronal biology, to aid in the interpretation of nuclear imaging of cardiac sympathetic innervation.