CBS 2019
CBSMD教育中心
中 文

Scientific Library

Abstract

Recommended Article

The Prevalence of Myocardial Bridging Associated with Coronary Endothelial Dysfunction in Patients with Chest Pain and Non-Obstructive Coronary Artery Disease Incremental Prognostic Value of Guideline-Directed Medical Therapy, Transradial Access, and Door-to-Balloon Time on Outcomes in ST-Segment-Elevation Myocardial Infarction Select Drug-Drug Interactions With Direct Oral Anticoagulants Coronary Access After TAVR State of the art: evolving concepts in the treatment of heavily calcified and undilatable coronary stenoses - from debulking to plaque modification, a 40-year-long journey Coronary calcification in the diagnosis of coronary artery disease Contemporary use of drug-coated balloons in coronary artery disease: Where are we now? Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial
|<<... 98 99 100 101 102 103 104 ...>>|

Original Research2019 Jan 15. [Epub ahead of print]

JOURNAL：EuroIntervention. Article Link

The Prevalence of Myocardial Bridging Associated with Coronary Endothelial Dysfunction in Patients with Chest Pain and Non-Obstructive Coronary Artery Disease

Sara JDS, Corban MT, Prasad M et al. Keywords: myocardial bridging; prevalence; coronary endothelial dysfunction; chest pain; angina; non obstructive CAD

ABSTRACT

AIMS - Myocardial bridging (MB), characterized by the epicardial coronary vessel diving into the myocardium, is present up to 1/3rd of adults and is associated with accelerated atherosclerosis, and angina. In the current study we determine the association between MB and coronary endothelial dysfunction.


METHODS AND RESULTS - Patients with chest pain and nonobstructive CAD (stenosis < 40%) at angiography underwent invasive assessment of endothelial function. Epicardial endothelial function was assessed by measuring the percent change in coronary artery diameter in response to intracoronary infusions of acetylcholine (%ΔCADAch). Epicardial endothelial dysfunction was defined as %ΔCADAch of < -20%. Microvascular endothelial function was assessed as the percent change in coronary blood flow in response to intracoronary infusions of acetylcholine (%ΔCBFAch), and microvascular endothelial dysfunction was defined as %ΔCBFAch of < 50%. MB was diagnosed angiographically. The frequency of epicardial and microvascular endothelial dysfunction was compared between patients with and without MB. Results Between 1993 and 2012, 1,469 patients (mean age 50.4 years, 35% male) underwent coronary angiography and invasive testing of endothelial function. Two hundred eight (14.2%) patients had MB. Patients with MB had a higher frequency of epicardial endothelial dysfunction compared to patients without MB. In multivariate analyses, MB was a significant predictor of epicardial (OR, 95% CI, 1.45, 1.05 - 2.01, p=0.026) and microvascular endothelial dysfunction (OR, 95% CI, 1.36, 1.00 - 1.85, p=0.047).


CONCLUSIONS - MB is significantly associated with epicardial and microvascular endothelial dysfunction in patients with non-obstructive CAD supporting its potential role as a mechanism for angina in symptomatic patients with MB.

>CBS CBS 2019

> CBS 2019 REGISTRATION

> CBS 2019 PROGRAM

> CBS 2019 CALL FOR SCIENCE

> CBS 2019 SPOTLIGHTS

 CBSMD

> CBSMD WEBSITE REGISTRATION

> EDUCATION CENTER

> RECOMMANDED PAPER

> TOP 10 RESEARCH PAPER

> PRE-READING

CBS 2019 CBS 2019 FACULTY Education Resource CBSMD Scientific Library
Copyright ⓒ CBS MD Nanjing China. All rights reserved. 京ICP备16025898号-11
联系我们| Top