CBS 2019
CBSMD教育中心
English

ASCVD Prevention

科研文章

荐读文献

Short-Term Progression of Multiterritorial Subclinical Atherosclerosis Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes The Burden of Cardiovascular Diseases Among US States, 1990-2016 Coronary calcium as a predictor of coronary events in four racial or ethnic groups ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography Burden of Cardiovascular Diseases in China, 1990-2016: Findings From the 2016 Global Burden of Disease Study Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines The Prevalence of Myocardial Bridging Associated with Coronary Endothelial Dysfunction in Patients with Chest Pain and Non-Obstructive Coronary Artery Disease Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies

Original Research2010 Jan;5(6):709-15.

JOURNAL:EuroIntervention. Article Link

Diffuse atherosclerotic left main coronary artery disease unmasked by fractal geometric law applied to quantitative coronary angiography: an angiographic and intravascular ultrasound study

Motreff P, Rioufol G, Gilard M et al. Keywords: diffuse atherosclerotic left main coronary artery disease; diffuse atheroma; LMCA; IVUS

ABSTRACT

AIMS - Angiographic analysis of left main coronary artery (LMCA) stenosis can be hindered by the lack of any reference segment when the LMCA is short or there is diffuse atheroma. Fractal geometric law (FGL) enables the theoretic diameter of one bifurcation vessel to be calculated from those of the other two (Dmother=0.678*(Ddaughter1+Ddaughter2). Applied to the LMCA, the FGL can help the quantification of stenoses.


METHODS AND RESULTS - Fifty-two patients with angiographically mild focal LMCA disease (n=14) or normal to nearly normal LMCA (n=38) who had undergone intravascular ultrasound (IVUS) were included. IVUS analysis confirmed all 14 focal stenoses (group C); of the 38 angiographically normal patients, however, 10 were found to present diffuse LMCA disease (group B), the remaining 28 showing a truly healthy LMCA (group A). LMCA stenosis in groups A,B and C was respectively 3%,4% and 42% on usual quantitative coronary angiography(QCA) and 5%, 31% and 43% on QCAfractal applying the FGL. In cases of diffuse atheroma, the FGL corrected the underestimation of LMCA diameter, which averaged 1.2 mm. conclusions: Angiographic underestimation of LMCA stenosis can be corrected by applying the FGL to obtain a theoretic LMCA diameter, thereby unmasking any diffuse atherosclerotic LMCA disease, or to quantify focal stenosis more precisely where the adjacent segments are also pathological.