CBS 2019
CBSMD教育中心
中 文

科学研究

Abstract

Recommended Article

Transcatheter Aortic Valve Replacement During Pregnancy Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial Coronary artery imaging with intravascular high-frequency ultrasound Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement Prior Pacemaker Implantation and Clinical Outcomes in Patients With Heart Failure and Preserved Ejection Fraction Combined use of OCT and IVUS in spontaneous coronary artery dissection Raising the Evidentiary Bar for Guideline Recommendations for TAVR: JACC Review Topic of the Week

Review Article2017 Aug 1;70(5):590-606.

JOURNAL:J Am Coll Cardiol. Article Link

Translational Perspective on Epigenetics in Cardiovascular Disease

van der Harst P, de Windt LJ, Chambers JC Keywords: EWAS; HAT; HDAC; RNA; histones; methylation

ABSTRACT

A plethora of environmental and behavioral factors interact, resulting in changes in gene expression and providing a basis for the development and progression of cardiovascular diseases. Heterogeneity in gene expression responses among cells and individuals involves epigenetic mechanisms. Advancing technology allowing genome-scale interrogation of epigenetic marks provides a rapidly expanding view of the complexity and diversity of the epigenome. In this review, the authors discuss the expanding landscape of epigenetic modifications and highlight their importance for future understanding of disease. The epigenome provides a mechanistic link between environmental exposures and gene expression profiles ultimately leading to disease. The authors discuss the current evidence for transgenerational epigenetic inheritance and summarize the data linking epigenetics to cardiovascular disease. Furthermore, the potential targets provided by the epigenome for the development of future diagnostics, preventive strategies, and therapy for cardiovascular disease are reviewed. Finally, the authors provide some suggestions for future directions.