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Improving the Design of Future PCI Trials for Stable Coronary Artery Disease: JACC State-of-the-Art Review Comparison of Heart Team vs Interventional Cardiologist Recommendations for the Treatment of Patients With Multivessel Coronary Artery Disease European Bifurcation Club White Paper on Stenting Techniques for Patients With Bifurcated Coronary Artery Lesions Invasive Coronary Physiology After Stent Implantation: Another Step Toward Precision Medicine Contrast-Associated Acute Kidney Injury and Serious Adverse Outcomes Following Angiography Digital learning and the future cardiologist The Year in Cardiovascular Medicine 2020: Coronary Intervention Novel functions of macrophages in the heart: insights into electrical conduction, stress, and diastolic dysfunction Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation The mSToPS Randomized Clinical Trial Catheterization Laboratory Considerations During the Coronavirus (COVID-19) Pandemic: From the ACC’s Interventional Council and SCAI
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Review Article2017 Jul 11;70(2):230-251.

JOURNAL：J Am Coll Cardiol. Article Link

Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series

Niemann B, Newby DE, Kovacic JC et al. Keywords: air pollution; atherosclerosis; diabetes; exhaust; inflammation; metabolic stress; obesity; particulate matter; tobacco

ABSTRACT

Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting. Here, we explore the role of different ROS sources arising in obesity and diabetes, and the effect of excessive ROS production on the development of cardiac lipotoxicity. In parallel, contaminants in the air that we breathe pose a significant threat to human health. This paper provides an overview of cigarette smoke and urban air pollution, considering how their composition and biological effects have detrimental effects on cardiovascular health.



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